The Journal of Clinical Psychiatry The Journal of Clinical Psychiatry

The Journal of
Clinical Psychiatry

Empowering mental health professionals with peer-reviewed psychiatric research and insights

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JCP
Algorithms for TRD Treatment Success
Insights

September 27, 2024

Dr. Nolan Williams delves into the innovative Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) for treating resistant depression. Explore groundbreaking research, clinical trials, and the transformative potential of personalized brain…
JCP
Changes in Cognition in Patients With Schizophrenia
Meta-Analysis

September 25, 2024

Only marginal improvements in cognition were seen over time; the greatest were achieved for patients with an illness duration shorter than 10 years.
JCP
Regression: Understanding What Covariates and Confounds Do in Adjusted Analyses
Clinical and Practical Psychopharmacology

September 18, 2024

Basic terms and concepts of regression analysis are presented, as well as three useful examples that involve readers in learning how regressions work.

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Case Reports

JCP
SSRI Discontinuation and AUD Relapse
Case Report

August 26, 2024

A man with AUD achieves sobriety on treatment with an SSRI and naltrexone, but then stops taking the SSRI to participate in a psilocybin “ceremony.” What factors contributed to…
JCP
Serotonin Syndrome and Dextromethorphan Toxicity Caused by Fluoxetine and Bupropion-Dextromethorphan Interaction
Case Report

April 3, 2024

Addition of bupropion-dextromethorphan (BUP/DXM) to existing fluoxetine treatment resulted in serotonin syndrome within 3 days, with symptoms prompting presentation to the ED 5 days after discontinuation of BUP/DXM.
JCP
Suicidality Emerging From Rapid Venlafaxine Discontinuation
Case Report

January 22, 2024

This case report presents a patient with no history of suicidal crisis who experienced 2 suicidal crises within 6 months, each directly following rapid discontinuation of venlafaxine.
JCP
Safety and Tolerability of Concomitant Intranasal Esketamine and MAOI Treatment
Case Report

February 1, 2023

Three cases suggest that concomitant use of intranasal esketamine with an irreversible, nonselective MAOI is safe in some patients.
JCP
Antidepressant Discontinuation Syndrome Resulting in a Suicide Attempt
Case Report

October 10, 2022

The authors report on a patient who attempted suicide after discontinuing antidepressant treatment and experiencing associated “electric shocks” and other symptoms.
JCP
Case Report

May 11, 2021

This report describes carbamazepine level fluctuations that occurred concurrent with stopping and restarting of cannabis use in a patient with bipolar disorder.

Topical Research

JCP
Medication Use and Lines of Treatment in Patients With Insomnia Disorder
Original Research

September 11, 2024

In this Canadian study, the annual cost of medications for insomnia was $54.8 million, and $30.3 million (55.2%) met inappropriate medication use criteria.
JCP
Bridge Symptoms Between Borderline Personality and PTSD
Original Research

September 9, 2024

Self-aggression, feelings of emptiness, dissociation, and feelings of detachment were found to be bridge symptoms between borderline personality disorder and PTSD. Targeting these might allow better prevention and management…
JCP
Collaborative vs Specialty Care for Depression or Anxiety
Original Research

September 4, 2024

Model effects at 6 months revealed that patients assigned to collaborative care showed significantly greater improvement than those assigned to specialty psychiatry.

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More JCP Articles

JCP
Diagnostic Assessment via Telehealth vs Face-to-Face
Systematic Review

September 16, 2024

Several small studies suggest that telehealth holds promise for psychiatric assessments, especially when in-person evaluations are not feasible.
JCP
Baseline Cognition Is Not Associated With Depression Outcomes in Vortioxetine
Original Research

September 4, 2024

This study suggests that cognitive function does not moderate depression outcomes in vortioxetine, with results comparable to other antidepressants.
JCP
Perinatal Timing of OCD Onset
Original Research

August 28, 2024

Findings show that OCD is most likely to begin in the early postpartum, with a rapid transition from symptoms to disorder. People with pre-existing OCD are vulnerable to symptom…
JCP
Reproductive Pharmacovigilance and Best Practices
Commentary

August 26, 2024

Dr Freeman discusses a recent study by Pacilio et al that characterized real world practices around ketamine treatment and pregnancy testing, consent processes, and contraception use. She emphasizes the…
JCP
Safe Ketamine Use and Pregnancy: A Nationwide Survey
Original Research

August 26, 2024

Risks of fetal ketamine exposure are often overlooked, indicating a need for awareness about reproductive concerns when prescribing ketamine for psychiatric disorders.
JCP
Olanzapine and Mirtazapine for Cancer-Related Anorexia
Clinical and Practical Psychopharmacology

August 21, 2024

Dr Andrade discusses two RCTs that investigated the utility of olanzapine and mirtazapine in addressing appetite loss in cancer patients.
JCP
Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia
Review Article

August 21, 2024

Patients with schizophrenia and cognitive impairment had a 100% increase in relapse-related hospitalizations and ER visits versus patients with no (or only mild) cognitive impairment.
JCP
Functional Unblinding in Pivotal Studies and the Future of Psychedelic Medicine
Commentary

August 21, 2024

Dr Rosenbaum comments on the challenge of evaluating trials of treatments whose effects are unmistakable, and how this dilemma may be addressed.
JCP
Adjunctive Treatment Targeting Multiple Mechanisms in Schizophrenia
Narrative Review

August 19, 2024

While the pathophysiology of schizophrenia is complex, treatments with novel pharmacological actions that target these systems are of interest as adjunctive treatment for schizophrenia.
JCP
Prevalence and Course of Unwanted, Intrusive Thoughts of Infant-Related Harm
Original Research

August 14, 2024

Although intrusive thoughts of accidental and intentional infant harm are a common and normative postpartum experience, they cause distress for many new mothers. Clinically significant symptoms that remain by…
JCP
Differentiation Across Bipolar Disorder and MDD by Whole-Night Polysomnographic Findings
Original Research

August 14, 2024

PSG-measured sleep abnormalities, such as reduced REM latency, may be a diagnostic differentiating factor between MDD and bipolar disorder.
JCP
Aripiprazole Lauroxil Initiation Regimens
Original Research

August 12, 2024

In separate studies of the two initiation methods, the numbers of people who had side effects were similar, and most side effects were mild.