Anticonvulsants as Mood Stabilizers and Adjuncts to Antipsychotics: Valproate, Lamotrigine, Carbamazepine, Oxcarbazepine and Actions at Voltage-Gated Sodium Channels

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The past several BRAINSTORMS features have discussed 3 major mechanisms of therapeutic action for anticonvulsants: enhancement of the inhibitory neurotransmitter GABA (γ-aminobutyric acid), blockade of voltage-gated calcium channels as α₂δ ligands, and blockade of voltage-gated sodium channels.^1-4