Brainstorms: Anticonvulsants as Anxiolytics, Part 2: Pregabalin and Gabapentin as α2δ Ligands at Voltage-Gated Calcium Channels

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Activation of fear circuits is a leading hypothesis for explaining symptoms in anxiety disorders,^1-3 and returning neurotransmission in these circuits to a more normal pattern may reduce certain symptoms.⁴ For example, anticonvulsants may theoretically reduce seizures by decreasing excessive output from epileptic neurons, and could, by analogy, reduce symptoms of anxiety if these agents were also able to decrease neuronal activation within fear circuits.^1-4