Brainstorms: Anticonvulsants and the Relief of Chronic Pain: Pregabalin and Gabapentin as α2δ Ligands at Voltage-Gated Calcium Channels

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Recent BRAINSTORMS features have highlighted the fact that anticonvulsants have several different mechanisms of action1 and that some of these mechanisms may also have therapeutic applications in anxiety disorders.^2,3 Last month we specifically reviewed a novel class of anticonvulsants with actions as ligands at the α2δ subunit of voltage-gated calcium channels.³