Drug Craving and Other Negative Reactions After Abrupt Substitution of Nefazodone for Other Serotonergic Agents

Letter to the Editor

Sir: Nefazodone is a relatively new antidepressant medication with a novel profile of neurochemical effects: potent blockade of the 5-HT2A receptor, inhibition of the serotonin reuptake pump at higher concentrations, and transient norepinephrine reuptake inhibition. Among the potential consequences of this profile include antidepressant and anxiolytic efficacy and decreased incidence of medication-related complaints of insomnia and anxiety. Given its reputed lack of sexual side effects, nefazodone is now regarded as a particularly useful option in cases where these side effects interfere with patient satisfaction and compliance with treatment.