A Roadmap to Key Pharmacologic Principles in Using Antipsychotics: Application in Clinical Practice

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The publication Translating the Psychopharmacology of Antipsychotics to Individualized Treatment for Severe Mental Illness: A Roadmap outlined key pharmacologic principles concerning the use of antipsychotics. In keeping with the recommendation of the President’s New Freedom Commission on Mental Health to incorporate the latest scientific information into mainstream health care as rapidly as possible, the Roadmap drew on clinical trial data, information on antipsychotic pharmacology, practice guidelines, consensus statements, and expert opinion to develop recommendations for achieving best outcomes for individual patients. Expert opinion was sampled using an initial survey and roundtable meeting of 10 experts and a follow-up survey of 27 experts who reached a high level of consensus on many key questions not adequately addressed by the literature.