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Care Companionfor CNS Disorders

Advancing primary care with essential research and insights into CNS disorders

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JCP
Reproductive Pharmacovigilance and Best Practices
Commentary

August 26, 2024

Dr Freeman discusses a recent study by Pacilio et al that characterized real world practices around ketamine treatment and pregnancy testing, consent processes, and contraception use. She emphasizes the…
JCP
Safe Ketamine Use and Pregnancy: A Nationwide Survey
Original Research

August 26, 2024

Risks of fetal ketamine exposure are often overlooked, indicating a need for awareness about reproductive concerns when prescribing ketamine for psychiatric disorders.
JCP
Olanzapine and Mirtazapine for Cancer-Related Anorexia
Clinical and Practical Psychopharmacology

August 21, 2024

Dr Andrade discusses two RCTs that investigated the utility of olanzapine and mirtazapine in addressing appetite loss in cancer patients.
JCP
Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia
Review Article

August 21, 2024

Patients with schizophrenia and cognitive impairment had a 100% increase in relapse-related hospitalizations and ER visits versus patients with no (or only mild) cognitive impairment.
JCP
Functional Unblinding in Pivotal Studies and the Future of Psychedelic Medicine
Commentary

August 21, 2024

Dr Rosenbaum comments on the challenge of evaluating trials of treatments whose effects are unmistakable, and how this dilemma may be addressed.
JCP
Adjunctive Treatment Targeting Multiple Mechanisms in Schizophrenia
Narrative Review

August 19, 2024

While the pathophysiology of schizophrenia is complex, treatments with novel pharmacological actions that target these systems are of interest as adjunctive treatment for schizophrenia.
JCP
Prevalence and Course of Unwanted, Intrusive Thoughts of Infant-Related Harm
Original Research

August 14, 2024

Although intrusive thoughts of accidental and intentional infant harm are a common and normative postpartum experience, they cause distress for many new mothers. Clinically significant symptoms that remain by…
JCP
Differentiation Across Bipolar Disorder and MDD by Whole-Night Polysomnographic Findings
Original Research

August 14, 2024

PSG-measured sleep abnormalities, such as reduced REM latency, may be a diagnostic differentiating factor between MDD and bipolar disorder.
JCP
Aripiprazole Lauroxil Initiation Regimens
Original Research

August 12, 2024

In separate studies of the two initiation methods, the numbers of people who had side effects were similar, and most side effects were mild.
JCP
Symptomatic Disorders Comorbid with Borderline Personality Disorder Over Time
Original Research

August 7, 2024

Findings suggest that the absence of substance use disorders is the strongest predictor of achieving recovery from BPD.
JCP
Predictive Validity of Early Post-Injury CAPS-5 Score for Later PTSD Diagnosis
Original Research

August 5, 2024

A CAPS-5 score of ≥15 provided good predictive accuracy for subsequent PTSD development in the general injured population.
JCP
Sleep Disturbances and Perceived Stress in Substance Use Disorder Treatment
Original Research

July 31, 2024

Higher stress was associated with more severe insomnia, and vice versa, both at treatment intake and over the course of treatment, regardless of primary substance.