Primary Care Companion for CNS Disorders Primary Care Companion for CNS Disorders

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Care Companionfor CNS Disorders

Advancing primary care with essential research and insights into CNS disorders

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JCP
Immune Targeted Therapies for Depression: Antidepressant Effects of Monoclonal Antibodies
Narrative Review

June 24, 2024

Immune dysregulation may contribute to treatment resistance in depression. Monoclonal antibodies have shown promise in treating depression when used for inflammatory disorders and may offer new hope for patients…
JCP
Depression, Rumination, and Suicide Attempts in Adolescents With Mood Disorders: Sex Differences
Original Research

June 19, 2024

The authors found that in male adolescents, suicide attempts are mostly influenced by depressive symptoms. In female adolescents, depressive symptoms not only directly increase the risk of suicide attempts,…
JCP
Focus on Women’s Mental Health: Twenty Years and Counting
Editorial

June 17, 2024

On the anniversary of JCP’s Focus on Women’s Mental Health section, Marlene P. Freeman reflects on the past 20 years in women’s mental health care, including what has changed…
JCP
Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants
Original Research

June 17, 2024

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.
JCP
Cigarette Smoking and Tobacco Use Disorder Among US Adults
Original Research

June 12, 2024

The prevalence of daily smoking with tobacco use disorder (TUD) was 10 times that of daily cigarette smoking without TUD. But even nondaily smoking can produce or sustain TUD,…
JCP
Pharmacogenetic Phenotypes in a Perinatal Mental Health Clinic
Original Research

June 10, 2024

In patients of childbearing age who have had atypical responses or side effects to antidepressants, pharmacogenomic testing may be considered to guide dose or choice of agent. Dose adjustments…
JCP
Extreme Dysphoria of Pregnancy: A Distinct Syndrome Warranting Attention?
Commentary

June 10, 2024

Dr Freeman discusses the understudied phenomenon of pregnancy-related extreme dysphoria or depression, distinct from typical major depressive episodes. Three illustrative case vignettes are presented.
JCP
Why Ask Patients to Cut Into Quarters 10 mg THC Gummies From a Dispensary When 2.5 mg THC Is Available by Prescription?
Letter to the Editor

June 5, 2024

The authors discuss a study by Sawicki et al of dementia patients for whom 2.5 mg of THC was recommended for neuropsychiatric symptoms.
JCP
Accounting for Differences in Incident Guideline Discordant Prescribing for PTSD Among Women and Men Veterans
Original Research

June 5, 2024

Women Veterans with PTSD were 67% more likely to initiate a guideline discordant medication. More than half of this effect was explained by bipolar disorder, age, and prior psychiatric…
JCP
Epilepsy, Antiepileptic Drugs, and Adverse Pregnancy Outcomes, 1: Recent Research
Clinical and Practical Psychopharmacology

June 5, 2024

This article provides women who have epilepsy and who use antiepileptic drugs during pregnancy with information about the many risks to which they and their fetus/neonate are exposed at…
JCP
Cognitive Effects of ECT in Schizophrenia: A Review
Review Article

June 5, 2024

ECT was not associated with any significant cognitive deficits in people with treatment-resistant schizophrenia across global cognition, attention, language, visuospatial function, and executive function domains. The majority of studies…
JCP
THC Edible Gummies for Behavioral Symptoms of Dementia: Reply to Goldman and Markov
Letter to the Editor

June 5, 2024

The authors reply to Goldman and Markov’s comments on their recent study of dispensary-obtained THC for dementia.